TSLP and Immune Homeostasis
نویسندگان
چکیده
منابع مشابه
TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis
Whether thymic stromal lymphopoietin (TSLP) directly induces potent human CD4(+) T cell proliferation and Th2 differentiation is unknown. We report that resting and activated CD4(+) T cells expressed high levels of IL-7 receptor a chain but very low levels of TSLP receptor (TSLPR) when compared with levels expressed in myeloid dendritic cells (mDCs). This was confirmed by immunohistology and fl...
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متن کاملTSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses.
Thymic stromal lymphopoietin (TSLP) is crucial for the development of atopic diseases in humans and mice. Mice that express a lung-specific TSLP transgene (surfactant protein C promoter (SPC)-TSLP) develop a spontaneous and progressive asthma-like disease, suggesting that TSLP expression alone was sufficient for disease development. In this study, we show that, in fact, TSLP alone only causes a...
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If you suffer a skin allergy, don’t be so quick to blame your T cells; they might not be behind it. Allakhverdi and colleagues now show on page 253 that mast cells, activated by a cytokine from epithelial cells, can jumpstart T cell–independent inflammation. Skin and epithelial cells irritated by allergens or by injury produce a cytokine called thymic stromal lymphopoietin (TSLP). This cytokine...
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For millions of years, microbes have coexisted with eukaryotic cells at the mucosal surfaces of vertebrates in a complex, yet usually harmonious symbiosis. An ever-expanding number of reports describe how eliminating or shifting the intestinal microbiota has profound effects on the development and functionality of the mucosal and systemic immune systems. Here, we examine some of the mechanisms ...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2012
ISSN: 1323-8930
DOI: 10.2332/allergolint.11-rai-0394